For the past 10 years, Max Evans, his sister Isabel and his best friend Michael Guerin have been living a somewhat normal existence, with their hybrid biology of human and alien DNA helping them to fit in. Surviving descendants from beings on board the fiery crash of an alien spacecraft that popular legend says plummeted to the desert in 1947, the three teenagers have grown up quietly among the Roswell residents since emerging from incubation. Their peaceful existence was shattered the day Max forged an otherworldly connection with fellow classmate Liz Parker by using his mysterious powers to heal her gunshot wound, putting aside a pact of secrecy and ultimately risking his own life.

With this simple twist of fate, their secret was sacrificed and their identity exposed, forced to trust Liz and her best friends Maria DeLuca and Alex Whitman in order to stay one step ahead of forces from this world and beyond that would do anything to destroy them. They are also aided by Sheriff Valenti, who is driven by a very personal need to learn the truth about what happened on that fateful night in 1947.